Peter Parker is going through a major identity crisis. Burned out from being Spider-Man, he decides to shelve his superhero alter ego, which leaves the city suffering in the wake of carnage left by the evil Doc Ock. In the meantime, Parker still can't act on his feelings for Mary Jane Watson, a girl he's loved since childhood. A certain anger begins to brew in his best friend Harry Osborn as well...
Tobey Maguire Spider-Man / Peter Parker
Kirsten Dunst Mary Jane Watson
James Franco Harry Osborn
Alfred Molina Doc Ock / Otto Octavius
Rosemary Harris May Parker
J.K. Simmons J. Jonah Jameson
Donna Murphy Rosalie Octavius
Daniel Gillies John Jameson
Dylan Baker Dr. Curt Connors
Bill Nunn Joseph 'Robbie' Robertson
Vanessa Ferlito Louise
Aasif Mandvi Mr. Aziz
Willem Dafoe Green Goblin / Norman Osborn
Cliff Robertson Ben Parker
Ted Raimi Hoffman
Elizabeth Banks Miss Brant
Bruce Campbell Snooty Usher
Gregg Edelman Dr. Davis
Ilya Baskin Mr. Ditkovitch
Mageina Tovah Ursula
Daniel Dae Kim Raymond
Hal Sparks Elevator Passenger
Joel McHale Mr. Jacks
Stan Lee Man Dodging Debris
Kelly Connell Dr. Isaacs
Brent Briscoe Garbage Man
Emily Deschanel Receptionist
Jason Fiore-Ortiz Henry Jackson
Scott Spiegel Man on Balcony
Andy Bale OsCorp Executive
Christine Estabrook Mrs. Jameson
Molly Cheek Society Woman
John Paxton Houseman
Joy Bryant Woman at Web
Joanne Baron Skeptical Scientist
Peter McRobbie OsCorp Representative
Timothy Jerome Injured Scientist
Taylor Gilbert Mrs. Watson
Peter Vouras Stage Manager
Donnell Rawlings Pizza "Heist" Witness
Zachry Rogers Boy saved by Spider-Man
Ella Rogers Girl saved by Spider-Man
Louis Lombardi Poker Player
Marc John Jefferies Amazed Kid
Roshon Fegan Amazed Kid
Brendan Patrick Connor Theater Traffic Cop
Reed Diamond 'Algernon'
Dan Callahan 'Jack'
Elyse Dinh Violinist
John Landis Doctor
Tim Storms Chainsaw Doctor
Susie Park Clawing Nurse
Patricia M. Peters Screaming Nurse
Michael Edward Thomas Man at Fire
Anne Betancourt Woman at Fire
Venus Lam Child in Burning Building
Bill E. Rogers Fireman
Joe Virzi Fireman
Tom Carey Train Conductor
Jopaul Van Epp Boy with Mask
Weston Epp Boy with Mask
Peter Allas Train Passenger
Brianna Brown Train Passenger
Bill Calvert Train Passenger
Tony Campisi Train Passenger
Joey Diaz Train Passenger
Chloe Dykstra Train Passenger
Simone Gordon Train Passenger
Dan Hicks Train Passenger
Julia Max Train Passenger
Savannah Pope Train Passenger
Timothy Patrick Quill Train Passenger
Jill Sayre Train Passenger
Rickey G. Williams Train Passenger
Michael Arthur NYPD Officer (uncredited)
Frank Bonsangue Pizza Man (uncredited)
Cindy Cheung Chinese Daughter (uncredited)
Phil LaMarr Train Passenger (uncredited)
Andre M. Johnson Fireman 2 (uncredited)
Peter Cincotti Piano Player in Planetarium (uncredited)
Peyton List Little Girl Playing on Steps (uncredited)
Spencer List Little Boy Playing on Steps (uncredited)
Troy Metcalf Blue Collar Guy (uncredited)
Scott Ross Pedestrian (uncredited)
Bonnie Somerville Screaming Woman (uncredited)
Wesley Volcy Columbia University Student (uncredited)
Lou Volpe Man at Web (uncredited)
Garrett Warren Bearded Doctor (uncredited)
Joseph M. Caracciolo Priest at Mary Jane's Wedding (uncredited)
David Boston Pedestrian (uncredited)
Sho Brown Passenger (uncredited)
Sal Ardisi Parent (uncredited)
Edward Johnson Planetarium (uncredited)
Grant Curtis Hot Dog Vendor (uncredited)
Vince Cupone Victim (uncredited)
William E. Corcoran Stock Broker (uncredited)
Mohammed Hassan Middle Eastern Taxi Driver (uncredited)
Rachel Lehrer Hot Girl (uncredited)
Gene LeBell Train Passenger (uncredited)
Lorelei Llee Bank Employee (uncredited)
Joseph Nelson Extra (uncredited)
Claudia Katz Minnick Robbie's Assistant (uncredited)
Ronn Ozuk Cop (uncredited)
Denney Pierce Train Passenger (uncredited)
Carla Rhodes Phone Booth Girl (uncredited)
Randy Reinholz Train Passenger (uncredited)
Rachelle Roderick Jane, Engineer (uncredited)
Angel Katherine Taormina Female Onlooker on Street (uncredited)
Douglas Swander Train Passenger (uncredited)
Jimmy Star Reporter (uncredited)
Jack Wetherall Train Passenger (uncredited)
Ken Wharton Uptight Businessman (uncredited)
Henry Truong Doc Ock Lab Assistant #2 (uncredited)
Al Collado Cab Driver (uncredited)
Lee Cogburn Train Passenger (uncredited)
Sam Raimi University Student with Bag (uncredited)
John Cameron Man Buying 'Spider-Man No More' Newspaper (uncredited)