Robert Downey Jr. Sherlock Holmes

Jude Law Dr. John Watson

Rachel McAdams Irene Adler

Mark Strong Lord Henry Blackwood

Eddie Marsan Inspector Lestrade

Robert Maillet Dredger

Geraldine James Mrs. Hudson

Kelly Reilly Mary Morstan

William Houston Constable Clark

Hans Matheson Lord Coward

James Fox Sir Thomas Rotheram

William Hope Ambassador Standish

Clive Russell Captain Tanner

Oran Gurel Reordan

David Garrick McMurdo

Ky Discala Maid

Andrew Brooke Guard Captain

Tom Watt Carriage Driver

John Kearney Carriage Driver

Sebastian Abineri Coach Driver

Jonathan Gabriel Robbins Guard

James A. Stephens Captain Philips

Terence Taplin Groundskeeper

Bronagh Gallagher Palm Reader

Ed Tolputt Anonymous Man

Joe Egan Big Man

Jefferson Hall Young Guard

Miles Jupp Waiter

Marn Davies Police Officer

Andrew Greenough Prison Guard

Ned Dennehy Man with Roses

Martin Ewens Removable Man

Amanda Grace Johnson Young Woman Sacrifice

James Greene Governor

David Emmings Grave Policeman

Ben Cartwright Grave Policeman

Chris Sunley Grave Policeman

Michael Jenn Preacher

Timothy O'Hara Porter / Smith

Guy Williams Golden Dawn Envoy

Peter Miles Thug

Rocco Ritchie Boy in the Street (uncredited)