Will Smith Ben

Rosario Dawson Emily

Woody Harrelson Ezra Turner

Michael Ealy Ben's Brother

Barry Pepper Dan

Elpidia Carrillo Connie

Robinne Lee Sarah

Bill Smitrovich George Ristuccia

Joe Nuñez Larry

Sarah Jane Morris Susan

Connor Cruise Young Ben

Tim Kelleher Stewart Goodman

Gina Hecht Dr. Briar

Andy Milder George's Doctor

Judyann Elder Holly

Madison Pettis Connie's Daughter

Octavia Spencer Kate the Home Health Care Nurse

Robert Ochoa Choirboy (uncredited)

Bojana Novaković Julie

Sonya Eddy Nurse

Nichole Ambriz OR Nurse