Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.
Dwayne Johnson Frank Wolff
Emily Blunt Dr. Lily Houghton
Edgar Ramírez Lope de Aguirre
Jack Whitehall McGregor Houghton
Jesse Plemons Prince Joachim
Paul Giamatti Nilo
Veronica Falcón Trader Sam
Dani Rovira Sancho
Quim Gutiérrez Melchor
Dan Dargan Carter Gonzalo
Andy Nyman Sir James Hobbs-Coddington
Raphael Alejandro Zaqueu
Simone Lockhart Anna
Pedro Lopez Chief
Sulem Calderon Quila
Sebastian Blunt Society Guard
Mark Ashworth Society Member 1
Allan Poppleton Society Worker
Caroline Paige Kid Tourist
James Quattrochi Italian Tourist
Stephen Dunlevy Middlepart
Philipp Maximilian Axel
Romualdo Castillo Animal Vendor
Pedro Haro Bird Vendor
Christina Souza Barmaid
Michael H. Cole Bus Conductor
Hector Banos Puka Michuna Warrior
Peter Luis Zimmerman Puka Michuna Warrior
Travis Gomez Puka Michuna Warrior
David Lengel Boat Tourist
Justin Randell Brooke Boat Tourist
Piper Collins Boat Tourist
Keith Arthur Bolden Boat Tourist
Marcus Young Goon (uncredited)
Tanya Wheelock Boat Tourist (uncredited)
Robert Tinsley London Guard (uncredited)