Andrew returns to his hometown for the funeral of his mother, a journey that reconnects him with past friends. The trip coincides with his decision to stop taking his powerful antidepressants. A chance meeting with Sam - a girl also suffering from various maladies - opens up the possibility of rekindling emotional attachments, confronting his psychologist father, and perhaps beginning a new life.
Zach Braff Andrew Largeman
Natalie Portman Sam
Ian Holm Gideon Largeman
Peter Sarsgaard Mark
Jean Smart Carol
Armando Riesco Jesse
Jackie Hoffman Aunt Sylvia Largeman
Method Man Diego
Alex Burns Dave
Ron Leibman Dr. Cohen
Jim Parsons Tim
Michael Weston Kenny
Ann Dowd Olivia
Ato Essandoh Titembay
Denis O'Hare Albert
Trisha LaFache Kelly
Geoffrey Arend Karl Benson
George C. Wolfe Restaurant Manager
Austin Lysy Waiter
Gary Gilbert Young Hollywood Guy
Jill Flint Obnoxious Girl
Christopher Carley Gleason Party Drunk
Amy Ferguson Dana
Wynter Kullman Pam
Debbon Ayer Faye
Yvette Mercedes Neurology Receptionist
Jayne Houdyshell Mrs. Lubin
Soara-Joye Ross Handi-World Cashier
Joe Bacino Man Having Sex
Seth Michael May Peeping Tom
Kenneth Graymez Busboy
Ryan B. Moschetti Teen in Hallway
Tracey Antosiweicz Hooker
Ice Arthur-the-Dog
Magoo Masturbating Dog
Janine Strafaci Herself - News 12 New Jersey News Anchor (voice) (archive footage)
Kurt Siegelin Himself - News 12 New Jersey News Anchor (archive footage)