Leonardo DiCaprio Dr. Randall Mindy

Jennifer Lawrence Kate Dibiasky

Meryl Streep President Orlean

Cate Blanchett Brie Evantee

Rob Morgan Dr. Teddy Oglethorpe

Jonah Hill Jason Orlean

Mark Rylance Peter Isherwell

Tyler Perry Jack Bremmer

Timothée Chalamet Yule

Ron Perlman Benedict Drask

Ariana Grande Riley Bina

Kid Cudi DJ Chello

Himesh Patel Phillip

Melanie Lynskey June Mindy

Michael Chiklis Dan Pawketty

Tomer Sisley Adul Grelio

Paul Guilfoyle General Themes

Robert Joy Congressman Tenant

Jack Alberts Oliver

Ting Win

Lance A. Williams Daniel

Shimali de Silva Nisha

Hettienne Park Dr. Calder

Rafael Silva Nasa Scientist

Lonnie Farmer Old Aide #1

Homa Sarabi-Daunis White House Office Worker

Barbara Douglass Office Worker

Rena Maliszewski Anchor Reporting On Colon

Erik Parillo Sherriff Conlon

Robert Hurst Radochia Evan Mindy

Conor Sweeney Marshall Mindy

Ross Partridge Keith Ollens

Richard Donelly Old Aide #2

Liev Schreiber Bash Narrator (voice)

Samsara Yett Isherwell Child Aide

Meara Mahoney Gross Isherwell Child Aide

Jaden Onwuakor Isherwell Child Aide

Staci Roberts Linda Dicalio

Wendy Bellevue Isherwell Child Handler

Mishka Yarovoy Executive

Chris Everett Chief Editor Paula Woods

Annette Miller Mrs. Tanken

Stephen Thorne Benjamin

Aimee Doherty Passerby

Natalie Rebenkoff Talent PA

Gary Tanguay News Anchor #2

Georgia Lyman Groomer Thalia

Patricia DeHaney Hair Person

Ben Sidell Stage Manager

Therese Plaehn Autopsy Editor In Charge

Omar Ghonim Damian

Jody O'Neil Stage Manager #2

Meghan Leathers Media Quant

Ashleigh Banfield Dalia Hensfield

Sarah Silverman Sarah Benterman

Richard Snee Senator Lerner

Darryl Wooten FBI Agent

Danielle Waxman College Girl

Jeffrey Smith Blind Man FBI Agent

Jon Glaser Meow Man

Dorothy Dwyer Old Tough Lady

Odis Spencer Chief Justice

Sarah Nolen Sammy Puppeteer

Alvin Keith Harrison Telms

Alaina Pinto American Reporter

Lizzie Short French Reporter

Juri Love Japanese Reporter

Sujoy De Hindi Reporter

Brahms Guignard Haitian Reporter

Sergei Bushmanov Russian Reporter

Lewis D. Wheeler Mission Coordinator

Steve Gagliastro Onlooker

David J. Curtis Guy

Kevin Craig West Secretary of State

Alison Weller Secretary of Education

Rob Lévesque Secretary of Interior

Sam Zephir Captain

Dee Nelson Dr. Lisa Inez

Beau Allen Dr. Talcamont

Rebecca Gibel Waitress

Brian Faherty Guy from the Bar

Celeste Oliva Nearby Diner

Amanda Cass Rioting Patron

Roman Mitichyan Rioting Patron

Paul Marini Rioting Patron

Alex Huynh Rioting Patron

Michael Jibrin Federal Agent

Bill Mootos Federal Attorney

Patti Tippo French President

Allyn Burrows Mr. Dibiasky

Tori Davis Lawlor Mrs. Dibiasky

Joy Lang Housewife

June Holmes Girl in Commercial

Graham Holmes Boy in Commercial

Jacob Sanditen Yule's Friend

Anthony Marrese Other Friend

Caroline Bergwall Teen Girl Friend

Anania Williams Short Guy Friend

Nate Richman Stocky FBI Agent

Wes Johnson Don't Look Up'er

John Bucy Don't Look Up'er

Patrick Gover Don't Look Up'er

Conrad Perry Don't Look Up'er

Matt Rouillard Don't Look Up'er

Christopher Deschenes Don't Look Up'er

Patrick Michael Strange Just Look Up'er

J.P. Aaron Just Look Up'er

Daniela August Just Look Up'er

Nicholai Senat Puppet Show Kid

Alexandra Zilch Puppet Show Kid

Jonathan Kobs Truthslinger303

Bianca de la Garza Entertainment Journalist

Caitlin Ishibashi DJ at Concert

Claire Davis Bass Player

Elder Isaiah Perez Organ Player

Coran Spardakis Henley Drummer

Lance Norris Loyal Supporter

Ralph M. Studley Kid Rock Body Double

Frank Ridley Flight Director

Andrew Haserlat Mission Tech

Jayne McLendon Command Tech

Ishaan Khatter Raghav Manavalan

Khaldoun Rajeh Egyptian Family

Sheren Rajeh Egyptian Family

Khaled Rajeh Egyptian Family

Kareem Rajeh Egyptian Family

Ahmad Rajeh Egyptian Family

Adila Rajeh Egyptian Family

J.T. Turner Old Billionaire

Ed Peed Lobbyist

Zach Holmes #LaunchChallenge MeTuber (uncredited)

Chris Evans Devin Peters (uncredited)

Marissa Carpio Reporter with Big Hair (uncredited)

Luan Gallagher Boy looking at the meteor (uncredited)