Ryan Reynolds Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin Cable

Morena Baccarin Vanessa

Julian Dennison Firefist

Zazie Beetz Domino

T.J. Miller Weasel

Leslie Uggams Blind Al

Karan Soni Dopinder

Brianna Hildebrand Negasonic Teenage Warhead

Jack Kesy Black Tom

Eddie Marsan Headmaster

Shioli Kutsuna Yukio

Stefan Kapičić Colossus (voice)

Randal Reeder Buck

Nikolai Witschl Head Orderly Frye

Thayr Harris Sergei Valishnikov

Rob Delaney Peter

Lewis Tan Shatterstar

Bill Skarsgård Zeitgeist

Terry Crews Bedlam

Brad Pitt Vanisher

Paul Wu Hong Kong Boss

Robert Maillet Sluggo

Alan Tudyk Luke - Redneck #1

Matt Damon Redneck #2

Michasha Armstrong Swat Captain (School)

Joe Doserro Bus Driver

Hayley Sales Cable's Wife

Islie Hirvonen Cable's Daughter

Jagua Arneja Tree Trimmer #1

Gerry South Tree Trimmer #2

Mike Dopud Prison Guard

Luke Roessler Cereal Kid

Andy Canete Neighbor #1

Tanis Dolman Neighbor #2

Eleanor Walker Neighbor #3

Hunter Dillon Branding Boy

Sala Baker Older Firefist

Sonia Sunger News Reporter (Irene)

Paul Wernick News Cameraman

Rhett Reese News Helicopter Pilot

Abiola Uthman Chinook Pilot

Tony Bailey Black Tom Gang Member

David Cook Priest

Alex Kliner Park Bench Couple

Elaine Kliner Park Bench Couple

David Leitch Ground Chuck Mutant

Valencia Budijanto Zoo Kid

Stefania Indelicato Bystander

Myfanwy Williams Strip Club Dancer

Sam Armstrong Strip Club Dancer

Alison Pickford Strip Club Dancer

Danny Ocean Strip Club Baddie

Paul Lazenby Strip Club Baddie

Noah Beggs Strip Club Baddie

Andrei Kovski Strip Club Baddie

Alicia Morton Vocalist on 'Tomorrow' (voice)

Andre Tricoteux On-Set Colossus (uncredited)

Lisa Bunting Child Protection Worker (uncredited)

Miles Ellis Waving Prisoner (uncredited)

Lars Grant Prison Guard 96S (uncredited)

Sam Hargrave DMC Guard (uncredited)

Nicholas Hoult Beast (uncredited)

Simon MacIntyre Business Passerby (uncredited)

James McAvoy Charles Xavier (uncredited)

Evan Peters Quicksilver (uncredited)

Tye Sheridan Cyclops (uncredited)

Alexandra Shipp Storm (uncredited)

Kodi Smit-McPhee Nightcrawler (uncredited)

Scott Vickaryous Thug (uncredited)

Dan Zachary Mutant Prisoner (uncredited)